解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The treatment and management of ocular allergy (OA) remain a major concern for different specialties, including allergists, ophthalmologists, primary care physicians, rhinologists, pediatricians, dermatologists, clinical immunologists, and pharmacists. We performed a systematic review of all relevant publications in M...
journal_title:Allergy
pub_type: 杂志文章,meta分析
doi:10.1111/all.13786
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Epicutaneous sensitization is an important route of immunization for allergens in atopic diseases; however, studies have also shown that application with protein on the intact skin induces antigen-specific tolerance. Langerhans cells (LCs) play an immunosuppressive role in several inflammatory skin diseases ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13813
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The genetic determinants of food allergy have not been systematically reviewed. We therefore systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation. METHODS:We searched three electronic databases (MEDLINE, EMBASE and PubMed) on 9 January 2018...
journal_title:Allergy
pub_type: 杂志文章,meta分析
doi:10.1111/all.13767
更新日期:2019-09-01 00:00:00
abstract::Birch and other related trees of the families Betulaceae and Fagaceae (alder, hazel, oak, hornbeam, chestnut, and beech) constitute the birch homologous group. This grouping is primarily based on the extensive IgE cross-reactivity of allergen homologs to the major birch allergen Bet v 1. Birch pollen is the most domin...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.13758
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:The role of arachidonic acid metabolites in NSAID-induced hypersensitivity has been studied in depth for NSAID-exacerbated respiratory disease (NERD) and NSAID-exacerbated cutaneous disease (NECD). However, no information is available for NSAID-induced urticarial/angioedema (NIUA), despite it being the most ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13725
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:The nasal allergen challenge (NAC) is a useful tool for the diagnosis of allergic rhinitis (AR) and local allergic rhinitis (LAR) and might serve to design and monitor allergen immunotherapy. Nevertheless, data about its safety and reproducibility are scarce. OBJECTIVE:To investigate the safety and reproduc...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13728
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Hippo-Yes-associated protein (YAP) pathway plays an important role in epithelial cell proliferation and development. However, its possible role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unknown. We aim to investigate it on nasal epithelial proliferation and remodeling in CRSwNP. METHODS:T...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13647
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Insect-bite hypersensitivity (IBH) in horses is a chronic allergic dermatitis caused by insect bites. Horses suffer from pruritic skin lesions, caused by type-I/type-IV allergic reactions accompanied by prominent eosinophil infiltration into the skin. Interleukin-5 (IL-5) is the key cytokine for eosinophils ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13659
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Staphylococcus aureus (S. aureus) is frequently detected in the skin of patients with atopic dermatitis (AD), and involved in the flare of AD. There are some evidence-specific strains of S. aureus affect the severity of AD. However, the mechanism of predominant colonization and the aggravation of dermatitis ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13622
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:In high-risk populations, allergen-specific prophylaxis could protect from sensitization and subsequent development of allergic disease. However, such treatment might itself induce sensitization and allergies, thus requiring hypoallergenic vaccine formulations. We here characterized the preventive potential ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13573
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:The world's most catastrophic and deadly thunderstorm asthma epidemic struck Melbourne, Australia, on November 21, 2016. OBJECTIVE:Among thunderstorm-affected patients presenting to emergency rooms (ERs), we investigated risk factors predicting severe attacks requiring admission to hospital. METHODS:Thunde...
journal_title:Allergy
pub_type: 杂志文章,多中心研究
doi:10.1111/all.13609
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Airway epithelial injury is a crucial component of acute and severe asthma pathogenesis and a promising target for treatment of refractory asthma. However, the underlying mechanism of epithelial injury remains poorly explored. Although high levels of polyamines, mainly spermine, have been found in asthma and...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13472
更新日期:2018-10-01 00:00:00
abstract::Although nasal hyperreactivity (NHR) is a common feature in patients suffering from allergic and nonallergic rhinitis, it is widely neglected during history taking, underdiagnosed in the majority of patients with rhinitis and rhinosinusitis, not considered as an outcome parameter in clinical trials on novel treatments...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.13453
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:The use of allergen immunotherapy (AIT) for allergic rhinitis and its clinical efficacy in clinical trials depends on the effective determination of pollen allergen exposure time periods. We evaluate pollen data from Germany to examine the new definitions on pollen season and peak pollen period start and end...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13487
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Group 2 innate lymphoid cells (ILC2s) were closely associated with asthma. However, there were no perspective studies about the effects of glucocorticoid on ILC2s in asthma patients. Our objective was to perform a perspective study and evaluate the ILC2 activity after glucocorticoid therapy in asthma patient...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13438
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Chitotriosidase (chitinase 1, Chit1), a major true chitinase in humans, is induced in childhood asthma and has been implicated in the pathogenesis of a variety of inflammatory and tissue remodeling responses. However, the role and the mechanisms that underlie these contributions to the diseases have not been...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13426
更新日期:2018-08-01 00:00:00
abstract::Quantitative risk assessment (QRA) for food allergens has made considerable progress in recent years, yet acceptability of its outcomes remains stymied because of the limited extent to which it has been possible to incorporate severity as a variable. Reaction severity, particularly following accidental exposure, depen...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.13405
更新日期:2018-07-01 00:00:00
abstract::The care of patients with difficult-to-control asthma ("difficult asthma") is challenging and costly. Despite high-intensity asthma treatment, these patients experience poor asthma control and face the greatest risk of asthma morbidity and mortality. Poor asthma control is often driven by severe asthma biology, which ...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.13370
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Mastocytosis is a heterogeneous disease characterized by a clonal expansion of mast cells in various organs. The vast majority of patients suffer from signs and symptoms caused by mediator release from mast cells. Although the disease burden is high, there is currently no specific and validated instrument to...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13425
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Early-life sensitization to indoor allergens predicts asthma development. The aim of this study was to compare allergen concentrations in day-care centers (DCC) with those in private homes. METHODS:Settled airborne dust was collected 4 times a year from 20 German DCC (620 samples) and from the homes of chil...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13371
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Systemic allergic reactions are a risk for allergen immunotherapy that utilizes intact allergen preparations. We evaluated the safety, efficacy and immune mechanisms of short-course treatment with adjuvant-free Lolium perenne peptides (LPP) following a 6-week dose-escalation protocol. METHODS:In a prospecti...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13392
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Workplace exposure to trimellitic anhydride (TMA) can elicit TMA-specific IgE (sIgE), which may lead to occupational asthma (OA). An occupational immunosurveillance program (OISP) has been implemented to monitor TMA exposure and immunologic outcomes. The purpose of this study was to determine whether TMA-spe...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13348
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Lesions of bullous pemphigoid (BP), an autoimmune subepidermal blistering disease characterized by the presence of tissue-bound and circulating autoantibodies to hemidesmosomal antigens, harbor a mixed inflammatory cellular infiltrate. In various models, neutrophils, eosinophils, mast cells, monocytes as wel...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13376
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Allergen immunotherapy has been shown to be an effective treatment for local allergic rhinitis (LAR) to house dust mites. Studies with pollen allergen immunotherapy are limited to observational studies. The aim of this study was to evaluate the clinical efficacy and safety of Phleum pratense subcutaneous imm...
journal_title:Allergy
pub_type: 杂志文章,随机对照试验
doi:10.1111/all.13350
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Histamine intolerance is thought to trigger manifold clinical symptoms after ingesting histamine-rich food due to reduced activity of diamine oxidase (DAO). No study has hitherto systematically assessed daily fluctuations of histamine levels and DAO activities in symptomatic patients. The aim of the study wa...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13361
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Since 1988, numerous allergen immunotherapy guidelines (AIT-GLs) have been developed by national and international organizations to guide physicians in AIT. Even so, AIT is still severely underused. OBJECTIVE:To evaluate AIT-GLs with AGREE-II, developed in 2010 by McMaster University methodologists to compr...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13316
更新日期:2018-03-01 00:00:00
abstract::Elements are vital in airway mucosal physiology and pathology, but their distribution and levels in the mucosa remain unclear. This study uses the state-of-the-art nuclear microscopy facility to map and quantify multiple elements in the histology sections of nasal mucosa from patients with nasal polyps or inverted pap...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13329
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Epidemiologic evidence indicates a relevant association between atopic dermatitis (AD) and attention-deficit/hyperactivity disorder (ADHD). Underlying mechanisms and ways to best identify subgroups of AD patients at risk for ADHD are poorly understood. AIMS OF THE STUDY:To compare sociodemographic, clinical...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13326
更新日期:2018-03-01 00:00:00
abstract::Regulatory approaches for allergen immunotherapy (AIT) products and the availability of high-quality AIT products are inherently linked to each other. While allergen products are available in many countries across the globe, their regulation is very heterogeneous. First, we describe the regulatory systems applicable f...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.13266
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Chronic urticaria (CU) is a frequent skin disease characterized by relapsing appearance of pruritic hives. While clinical symptoms are due to the release of histamine by cutaneous mast cells, the underlying pathophysiology is still unknown. However, previous studies indicate that basophils might be of releva...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13215
更新日期:2017-12-01 00:00:00
abstract::The aim of this study was to investigate possible effects of landscape design on the IgE sensitization profile toward inhalant allergens in patients with respiratory allergy from Uzbekistan where green areas have been changed during the last two decades by a State program. Sera from two different generations of Uzbek ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13169
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Previous observational studies have implied breastmilk fatty acid composition may play a role in the development of atopic eczema or atopic sensitization in breastfed infants and toddlers. However, studies investigating associations with wheeze and asthma in later childhood are scarce and did not account for...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13161
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Spanish population is rather homogeneous in its genetic and sociocultural characteristics, but allergen sensitization shows wide geographical variations. We aimed at assessing whether sensitization to different allergens in the diverse geographical areas induced different clinical and quality-of-life charact...
journal_title:Allergy
pub_type: 杂志文章,多中心研究
doi:10.1111/all.13141
更新日期:2017-09-01 00:00:00
abstract::Group 2 innate lymphoid cells (ILC2s) are a recently identified group of cells with the potent capability to produce Th2-type cytokines such as interleukin (IL)-5 and IL-13. Several studies suggest that ILC2s play an important role in the development of allergic diseases and asthma. Activation of pulmonary ILC2s in mu...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.13139
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Adolescents have the highest risk for food allergy-related fatalities. Our main aim was to investigate the level of risk in everyday social situations as perceived by adolescents/young adults with peanut allergy, their families, and their friends. METHODS:The web-based 'Colours Of Risks' (COR) questionnaire...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13095
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Allergic asthma is a chronic airway inflammatory disease involving the complementary actions of innate and adaptive immune responses. Endogenously generated cannabinoids acting via CB2 receptors play important roles in both homeostatic and inflammatory processes. However, the contribution of CB2-acting eicos...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13107
更新日期:2017-06-01 00:00:00
abstract::A shared approach to decision-making framework has been suggested for chronic disease management especially where multiple treatment options exist. Shared decision-making (SDM) requires that both physician and patients are actively engaged in the decision-making process, including information exchange; expressing trea...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.13090
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:The role of fibrocytes in chronic obstructive pulmonary disease (COPD) is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease. METHODS:Utilizing flow cytometry to identify circulating, collagen type 1+ cells,...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13061
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Succinate, in addition to its role as an intermediary of the citric acid cycle, acts as an alarmin, initiating and propagating danger signals resulting from tissue injury or inflammatory stimuli. The contribution of this immune sensing pathway to the development of allergic and inflammatory responses is unkn...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13005
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Outside clinical trials, data on systemic reactions (SRs) due to allergen immunotherapy (AIT) are scarce. METHODS:A prospective, longitudinal, web-based survey of 'real-life' respiratory allergen immunotherapy (AIT) clinical practice was conducted in France, Germany and Spain. SRs were recorded and coded ac...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13066
更新日期:2017-03-01 00:00:00